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A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential for other cancers as well.
Scientists led by Olena Taratula, a nanomedicine researcher at Oregon State University, have found a way to better ensure the drug used to combat the disease reaches tumor cells without damaging healthy tissue.
Findings from the study into choriocarcinoma, which occurs in the United States at a rate of about four cases per 100,000 pregnancies, were published in Small Science. Typically, starting in the uterus, choriocarcinoma develops from cells that were part of the placenta. It can occur after a miscarriage, abortion or ectopic pregnancy, one in which a fertilized egg implants somewhere other than the lining of the uterus.
It can also happen following a molar pregnancy (no embryo forms, and the placental tissue grows abnormally) and even after a full-term pregnancy.
Taratula and collaborators, including OSU postdoctoral researcher Babak Mamnoon and Maureen Baldwin, a physician at Oregon Health & Science University, designed a type of drug nanocarrier known as a polymersome to specifically target a protein in choriocarcinoma cells.
Polymersomes are hollow spheres that are synthetic versions of liposomes, lipid-based sacs found in all living cells. The protein the researchers aimed for is equilibrative nucleoside transporter 1, usually abbreviated as ENT-1, which is important for a range of cellular processes, among them DNA and RNA synthesis.
In addition to being abundant in choriocarcinoma cells, ENT-1 is found in the brain, heart, liver and other tissues in the body.
Mamnoon led the research team in mouse model testing that confirmed attaching guanosine, a building block of RNA, to the polymersome allowed it to deliver more of the chemotherapy drug methotrexate directly to tumor cells.
“Given MTX’s role as the mainstay treatment for choriocarcinoma, the critical goal now is to enhance its effectiveness, including faster response times, while simultaneously minimizing side effects,” said Taratula, an associate professor in the OSU College of Pharmacy.
Methotrexate or MTX, a common cancer drug, works by interfering with cells’ ability to use folic acid, essential for making DNA and RNA. By blocking a certain enzyme, MTX thwarts replication of the otherwise rapidly dividing cancer cells.
Common symptoms of choriocarcinoma are pelvic pain and irregular vaginal bleeding. The cancer can quickly spread via the bloodstream to other parts of the body including bones, gastrointestinal tract, breasts kidneys liver, lungs, lymph nodes and brain.
