♦️Cancer cells use complex mechanisms to evade immune surveillance, with inhibition of apoptotic signaling being a key strategy. Apoptosis, or programmed cell death, is an important process of self-destruction of damaged or dysfunctional cells that prevents malignancy and maintains tissue homeostasis. In cancer, this pathway is often disrupted, allowing tumor cells to survive and proliferate … Read more
• Acetaminophen is a synthetic nonopiate derivative of p-aminophenol widely used in people for its antipyretic and analgesic properties. • It is rapidly absorbed from the Gl tract. • The metabolism of acetaminophen involves two major conjugation pathways in most species. Both involve cytochrome P450 metabolism, followed by glucuronidation or sulfation. • Cats are more … Read more
♦️The Renin-Angiotensin-Aldosterone System (RAAS) plays a critical role in maintaining blood pressure and fluid balance, making it a cornerstone of cardiovascular and renal physiology. This intricate system consists of hormones like renin, angiotensin, and aldosterone, which work in harmony to regulate vascular tone, sodium retention, and potassium excretion. ♦️The Renin-Angiotensin-Aldosterone System (RAAS) plays a crucial … Read more
♦️Bacteriophages, or phages, are viruses that specifically infect and kill bacteria, offering a potential alternative to traditional antibiotics. These viruses are highly selective, targeting specific bacterial species. For example, in the case of Escherichia coli (E. coli), the bacteriophage first attaches to the bacterial cell surface using specific receptors. After attachment, the phage injects its … Read more
Global Orally Disintegrating Tablet Market Overview: An Orally Disintegrating Tablet is a drug dosage form available for a limited range of over-the-counter and prescription medications. It differs from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole. ODTs dissolve or disintegrate in the mouth without water within … Read more
🔷Kidney disease means your kidneys aren’t working properly and are beginning to lose their function. Chronic kidney disease (CKD) worsens over time. High blood pressure and diabetes are two common causes of CKD. There’s no cure for CKD, but you can take steps to preserve function for as long as possible. Late-stage kidney disease requires … Read more
🔷Tumors exploit metabolic pathways to create an immunosuppressive microenvironment that allows them to evade immune surveillance and thrive. Changes in tumor metabolism, including glycolysis, lipid metabolism, and amino acid utilization, can significantly affect immune cell function within the tumor microenvironment (TME). 🔷A key metabolic change is the Warburg effect, whereby tumor cells favor glycolysis and … Read more
We recognize the invaluable role that care partners play in the lives of those impacted by Parkinson’s disease (PD). These unsung heroes provide daily support, encouragement, and compassion, tirelessly helping their loved ones. Our team is committed to supporting not only patients but the broader PD community, including these dedicated care partners. We aim to … Read more
The European Society for Medical Oncology (ESMO) Asia Congress will be held in Singapore. Lepu Biotech will present new Phase II clinical data on their EGFR-targeting ADC drug, MRG003, in combination with the PD-1 antibody, pitilimab, for the treatment of EGFR-mutated, recurrent, or metastatic nasopharyngeal carcinoma (NPC) at the conference. The Phase II clinical trial … Read more
Malaria, caused by the Plasmodium parasite, primarily targets the bloodstream, where it infects red blood cells. The life cycle of Plasmodium involves transmission through an infected Anopheles mosquito, with the parasites entering the human bloodstream and traveling to the liver to mature. Once in the bloodstream, they invade red blood cells, where they multiply, leading … Read more
