Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Summary ♦️Phagocytes are generally capable of en- gulfing and eliminating apoptotic cells without initiating the CGAS-STING path- ways that are triggered by cytosolic dou- ble-stranded DNA. ♦️ How phagocytes are therefore able to detect DNA-damaged cells that are potentially precancerous or virally infected is not well understood. Park et al. report that DNA-damaged cells initiate … Read more